Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Cardiovascular, Case Report
Cardiovascular, Editorial
Cardiovascular, Images in Cardiology
Cardiovascular, Interventional Round
Cardiovascular, Original Article
Cardiovascular, Preface
Cardiovascular, Review Article
Cardiovascular, Student’s Corner
Case Report
Case Reports
Clinical Discussion
Clinical Rounds
CPC
Debate
Dedication
Editorial
Expert Comments
Expert's Opinion
Genetic Autopsy
Genetics Autopsy
Image in Cardiology
Images in Cardiology
Interventional Round
Interventional Rounds
Letter to the Editor
Media and news
Original Article
Practice in Medicine
Preface
Review Article
Scientific Paper
Short Communication
Student's Corner
WINCARS Activities
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Cardiovascular, Case Report
Cardiovascular, Editorial
Cardiovascular, Images in Cardiology
Cardiovascular, Interventional Round
Cardiovascular, Original Article
Cardiovascular, Preface
Cardiovascular, Review Article
Cardiovascular, Student’s Corner
Case Report
Case Reports
Clinical Discussion
Clinical Rounds
CPC
Debate
Dedication
Editorial
Expert Comments
Expert's Opinion
Genetic Autopsy
Genetics Autopsy
Image in Cardiology
Images in Cardiology
Interventional Round
Interventional Rounds
Letter to the Editor
Media and news
Original Article
Practice in Medicine
Preface
Review Article
Scientific Paper
Short Communication
Student's Corner
WINCARS Activities
View/Download PDF

Translate this page into:

Editorial
06 (
02
); 098-099
doi:
10.1055/s-0041-1732505

Role of White blood Cell Count and Mean Platelet Volume ratio in Acute Coronary Syndrome patients: A short study

Dept. Laboratory, Aster Prime Hospital, Hyderabad, India
Address for correspondence Dr. S. Rama Devi, MBBS, MD, MBA, Consultant Pathologist Dept. Laboratory Aster Prime Hospital, Hyderabad India drseerararamadevi@gmail.com
Licence
This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Disclaimer:
This article was originally published by Thieme Medical and Scientific Publishers Pvt. Ltd. and was migrated to Scientific Scholar after the change of Publisher; therefore Scientific Scholar has no control over the quality or content of this article.

Abstract

Abstract

The white blood cell count to mean platelet volume ratio is an indicator of inflammation in patients with atherosclerotic disease. Acute coronary syndrome is a disease characterized in most of the cases by rupture of atherosclerotic plaque and subsequent complete or incomplete thrombosis of the coronary arteries.

Keywords

ACS
WMR
MACE
TAT

Introduction

That white blood cells (WBC) count to mean platelet volume (MPV) ratio (WMR) is an inflammatory marker in atherosclerotic diseased patients is already established. The characteristic feature of acute coronary syndrome (ACS) is rupture of atherosclerotic plaque, which is seen in in an increasing number of cases either by complete or incomplete occlusion of coronary arteries via thrombus formation.1

The potential role of leukocytes is proven in cardiovascular events. After an endothelial injury, T-cell and macrophage are activated, which are present in atherosclerotic plaque which, in turn, leads to the production of procoagulants and cytokines, thereby leading to the formation of thrombus.2

Also, there are studies which have suggested that platelets (both activated and inactivated forms) have a role to play in inflammatory pathways of acute coronary events by the production of adhesion molecules and cytokines, leading to atherogenesis.

At the site of plaque rupture, there is an enhancement of leucocytes due to interaction between platelets and leukocytes.

All these events and processes are important in elevating ACS development and its prognosis

It has been reported that the associated factors of cardiovascular morbidity and mortality are leukocyte differentials and platelet activation markers and; comorbidities such as hypertension, diabetes mellitus, obesity, and hypercholesterolemia are also associated with them.

This marker is cost-effective and easily available in complete blood picture; moreover, turnaround time (TAT) is less.

At the time of admission in patients with ACS, elevated WMR has more risk in multivessel disease and mortality when compared to lower WMR, therefore major adverse cardiac events (MACE) and worse outcomes can be predicted.3 4

It has been reported that high risk is seen in young women with ACS.5

An article titled, “Usefulness of WBC count to Mean platelet volume ratio in predicting short term (30 days) major adverse cardiac events in patients presenting with Acute Coronary Syndrome and its comparison in males and females” published in this journal has relevance and is significant, as only a few studies have been done as per literature.

In this current study, the best part was gender comparison; besides, other factors such as noninvasiveness, being easily accessible for interpretation, and short TAT are helpful for early diagnosis and management of MACE events and ACS.

This study involves a wide range of investigations done like CPK, LDH, AST, ALT, ALP, bilirubin, urea, creatinine, and lipid profile, but its importance/effect on short-term MACE was not explained in detail, and interdependence with WMR was also not established.

The key article was not relevant; also, sample size and duration of the study were less. Equipment and diagnostic criteria like Wilson score references (article) and regional variations in other countries were not described in the study.

Overall, even though it is statistically significant, further research in large study subjects is required in India to understand the role and importance of WMR, which helps ACS patients in predicting MACE and its treatment, a game changer in life-saving measures.

Conflict of Interest

None declared.

References

  1. , , , , , . Relationship between White blood cell count and mean platelet volume Ratio and clinical outcomes and severity of coronary artery disease in patients undergoing primary percutaneous coronary intervention. Cardiovasc Ther. 2020;2020:9625181.
    [Google Scholar]
  2. , , , et al . Prognostic value of blood count parameters in patients with acute coronary syndrome. Indian Heart J. 2018;70(02):233-240.
    [Google Scholar]
  3. , , , , , , . Usefulness of white blood cell count to mean platelet volume ratio in the prediction of SYNTAX score in patients with non-ST elevation myocardial infarction. Pak J Med Sci. 2019;35(03):824-829.
    [Google Scholar]
  4. , , , . Usefulness of white blood cell count to mean platelet volume ratio in predicting short term, 30 days major adverse cardiac events in patients presenting with acute coronary syndrome. International J Res Med Sci. 2020;8(04):1404-1413.
    [Google Scholar]
  5. , , , , , , . Acute coronary syndrome in young women under 55 years of age: clinical characteristics, treatment, and outcomes. Clin Res Cardiol. 2015;104(08):648-55.
    [Google Scholar]

Fulltext Views
16

PDF downloads
1
View/Download PDF
Download Citations
BibTeX
RIS
Show Sections