Abstract

Background: The aging of the population worldwide will result in increasing numbers of elderly patients, among whom heart disease is the leading cause of death. Changes in cardiovascular physiology with normal aging and prevalence of comorbidities are different between both sex. This results in differences in the effects of common cardiac problems as well as the response to their treatments. Clinical trials in octogenarians and nonagenarians PCI results are limited. The present study aims to analyze the gender variations in respect to the success of PCI in this elderly population.

Methods: This is a retrospective observational study of patients aged ≥ 80 yrs. with cardiovascular disease undergoing PCI. The prevalence of variables like age distribution, type of presentation, and pattern of angiographic profile, requirement of pre-dilation before stenting and success of PCI has been compared between male and female population. Student “t” test is used for comparison.

Results: The study population consists of 174 patients with female to male ratio of 1:3.7. The mean age is 82.4 ± 2.9 yrs in males and 82.2±2.9 yrs. in females. The minimum age is 80 and maximum is 99 yrs. 74(54%) male patients and 20 (54.1%)) female patients presented with chronic stable angina. Incidence of single vessel disease among male population is 97 (70.8%) and female population is 23 (62.1%) (p value=0.3). Rest of them are multi vessel disease. Pre-dilatation is required in 89% male patients and 86% female patients (95% CI = 0.09 to 0.14, P-Value = 0.7). LAD, LCX and RCA angioplasties are comparable between the both groups. Three LMCA PCI in females and 3 SVG PCI in males were done. Successful PCI done in 132 (96.4%) male patients and 35 (94.6%) female patients (p=0.7; CI-0.09 to 0.06).

Conclusion: Clinical and demographic features including success of PCI are similar in both female and males in octogenarians and nonagenarians who are undergoing PCI for CAD.