Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Abstracts
Cardiovascular, Case Report
Cardiovascular, Commentary
Cardiovascular, Editorial
Cardiovascular, Guest Editorial
Cardiovascular, Images in Cardiology
Cardiovascular, Interventional Round
Cardiovascular, Original Article
Cardiovascular, Perspective Review
Cardiovascular, Preface
Cardiovascular, Review Article
Cardiovascular, Student’s Corner
Case Report
Case Report, Cardiovascular
Case Reports
Case Series, Cardiovascular
Clinical Discussion
Clinical Rounds
CPC
Current Issue
Debate
Dedication
Editorial
Editorial Cardiovascular
Editorial, From the Publisher’s Desk
Expert Comments
Expert's Opinion
Genetic Autopsy
Genetics Autopsy
Guest Editorial, Cardiovascular
Image in Cardiology
Images in Cardiology
Images in Cardiology, Cardiovascular
Interventional Round
Interventional Round, Cardiovascular
Interventional Rounds
Letter to Editor
Letter to the Editor
Media and news
Original Article
Original Article, Cardiovascular
Original Article, Cardiovascular Health
Practice in Medicine
Preface
Review Article
Review Article, Cardiovascular
Scientific Paper
Short Communication
Student's Corner
Supplementary
Supplemetary
WINCARS Activities
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Abstracts
Cardiovascular, Case Report
Cardiovascular, Commentary
Cardiovascular, Editorial
Cardiovascular, Guest Editorial
Cardiovascular, Images in Cardiology
Cardiovascular, Interventional Round
Cardiovascular, Original Article
Cardiovascular, Perspective Review
Cardiovascular, Preface
Cardiovascular, Review Article
Cardiovascular, Student’s Corner
Case Report
Case Report, Cardiovascular
Case Reports
Case Series, Cardiovascular
Clinical Discussion
Clinical Rounds
CPC
Current Issue
Debate
Dedication
Editorial
Editorial Cardiovascular
Editorial, From the Publisher’s Desk
Expert Comments
Expert's Opinion
Genetic Autopsy
Genetics Autopsy
Guest Editorial, Cardiovascular
Image in Cardiology
Images in Cardiology
Images in Cardiology, Cardiovascular
Interventional Round
Interventional Round, Cardiovascular
Interventional Rounds
Letter to Editor
Letter to the Editor
Media and news
Original Article
Original Article, Cardiovascular
Original Article, Cardiovascular Health
Practice in Medicine
Preface
Review Article
Review Article, Cardiovascular
Scientific Paper
Short Communication
Student's Corner
Supplementary
Supplemetary
WINCARS Activities
Generic selectors
Exact matches only
Search in title
Search in content
Post Type Selectors
Search in posts
Search in pages
Filter by Categories
Abstracts
Cardiovascular, Case Report
Cardiovascular, Commentary
Cardiovascular, Editorial
Cardiovascular, Guest Editorial
Cardiovascular, Images in Cardiology
Cardiovascular, Interventional Round
Cardiovascular, Original Article
Cardiovascular, Perspective Review
Cardiovascular, Preface
Cardiovascular, Review Article
Cardiovascular, Student’s Corner
Case Report
Case Report, Cardiovascular
Case Reports
Case Series, Cardiovascular
Clinical Discussion
Clinical Rounds
CPC
Current Issue
Debate
Dedication
Editorial
Editorial Cardiovascular
Editorial, From the Publisher’s Desk
Expert Comments
Expert's Opinion
Genetic Autopsy
Genetics Autopsy
Guest Editorial, Cardiovascular
Image in Cardiology
Images in Cardiology
Images in Cardiology, Cardiovascular
Interventional Round
Interventional Round, Cardiovascular
Interventional Rounds
Letter to Editor
Letter to the Editor
Media and news
Original Article
Original Article, Cardiovascular
Original Article, Cardiovascular Health
Practice in Medicine
Preface
Review Article
Review Article, Cardiovascular
Scientific Paper
Short Communication
Student's Corner
Supplementary
Supplemetary
WINCARS Activities
View/Download PDF

Translate this page into:

Original Article
02 (
01
); 030-035
doi:
10.1055/s-0038-1656456

Comparision Between Clopidogrel and Prasugrel On hs-CRP Levels Post Percutaneous Intervention

Senior Resident, Department of Cardiology, NIMS, India
Ph D student, Department of Cardiology, NIMS, India

ashokari@gmail.com

Licence
This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Disclaimer:
This article was originally published by Thieme Medical and Scientific Publishers Private Ltd. and was migrated to Scientific Scholar after the change of Publisher.

Abstract

Abstract

Aims: This study investigated the effect of clopidogrel versus prasugrel treatment on inflammatory activity as evidenced by high-sensitivity C-reactive protein (hs-CRP) levels among patients who underwent percutaneous intervention (PCI). The effect in clinical outcomes between both the treatment groups is also explored.

Methods: The study included 53 patients into two cohorts with 30 from clopidogrel group and 23 from prasugrel group who underwent PCI for coronary artery disease. Patients were assigned either to clopidogrel or prasugrel group based on mehraan bleeding risk score. Hs-CRP was measured on 15thfollowup day. The predefined primary composite endpoint was myocardial infarction, stroke, vascular complications or death from cardiovascular causes.

Results: In both treatment groups the changes in hs-CRP levels over time were identical (2.97±3.2 in clopidogrel vs. 4.47±4.1in prasugrel p:0.14). Clinical outcomes occurred in 3 cases in clopidogrel group and one patient had puncture site hematoma in prasugrel group (p: 0.72). In contrast no significant difference in hs-CRP was noted among those had adverse clinical outcomes (1.67±2.2 vs 3.12±3.3 p: 0.47). Baseline parameters height (158.3±7.7 vs 157.8±7.7p:0.80) weight (63.4±9.7 vs 63.8±9.6 p: 0.87) hypertension (17 vs 11 p: 0.58) diabetes (11 vs 8 p: 1.00) smokers (1 vs. 5 p: 0.06) are matched between both the groups. Clopidogrel group were elderly (63.1±9.6 vs 53.7±9.5 p: 0.001) and had higher systolic blood pressure (154.7±26.2 vs 138.7±18.7 p: 0.01). Clinical scenario like type of presentation (CSA 16 vs 9 p: 0.29) LV dysfunction (10 vs 10 p: 0.57) previousPCI (5 vs 4 p: 0.94) previous CABG (2 vs 0 p: 0.143) are identical in both groups. Lesion characteristics like calcification (15 vs 11 p:0.97) tortuosity(4 vs 3 p:0.94) angulation (2 vs 0p:0.49) ostial lesion ( 8 vs 5 p:0.75) thrombotic (0 vs 1 p:0.30) was similar in both the groups. Bifurcation lesion (6 vs 1 p:0.06) usage of Gp2B3A inhibitors(3 vs 0 p:0.06) was higher in clopidogrel group.

Conclusions: Antiplatelet prasugrel and clopidogrel significantly did not affect inflammation post PCI as assessed by hs-CRP which is an established inflammatory marker. No significant difference in clinical outcomes in the follow-up between both the groups. Neither hs-CRP level was elevated in those with adverse clinical events.

Keywords

Clopidogrel
Prasugrel
hs-creative protein
inflammatory markers
platelet aggregation

Fulltext Views
420

PDF downloads
525
View/Download PDF
Download Citations
BibTeX
RIS
Show Sections